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NIH Research Program Projects (Parent P01 Clinical Trial Optional)

National Institutes of Health

Through this Notice of Funding Opportunity (NOFO), the participating NIH Institutes, Centers, and Offices (ICOs) invite applications for the investigator-initiated Program Project (P01). A P01 supports a broadly based, multidisciplinary research program with a specific major scientific objective or theme. The proposed

Funding
See official notice
Deadline
May 25, 2029
Status
OPEN
Category
Research & Science
Opens
October 14, 2026
Directory link check
October 22, 2026

About this opportunity

Through this Notice of Funding Opportunity (NOFO), the participating NIH Institutes, Centers, and Offices (ICOs) invite applications for the investigator-initiated Program Project (P01). A P01 supports a broadly based, multidisciplinary research program with a specific major scientific objective or theme. The proposed Program Projects are focused on the programmatic interests of one or more of the participating ICOs based on their scientific missions. A program project utilizes research projects with a common central scientific theme, an administrative core, and optional shared resource core(s) to accomplish ICOs' programmatic objectives.

Eligibility recorded

Special district governments; Public and State controlled institutions of higher education; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Private institutions of higher education; City or township governments; State governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Native American tribal organizations (other than Federally recognized tribal governments); Others (see text field entitled "Additional Information on Eligibility" for clarification); Public housing authorities/Indian housing authorities; County governments; For profit organizations other than small businesses; Small businesses; Native American tribal governments (Federally recognized); Independent school districts

Recorded geography: United States

Applicant types

Focus areas

Research & Science, Health

Directory verification note

Automatically synchronized from Grants.gov Full Taxonomy Expansion. Source identifier: 361279. Confirm details on the official page. This product uses the Grants.gov API but is not endorsed or certified by the U.S. Department of Health and Human Services.

Recorded notice evidence

What to verify for NIH Research Program Projects (Parent P01 Clinical Trial Optional)

Applicant evidence

  • Applicant type: Government organizations
  • Applicant type: Universities and higher-education institutions
  • Applicant type: Nonprofit organizations
  • Applicant type: Tribal governments
  • Applicant type: Small businesses
  • Applicant type: SCHOOLS
  • Geography: United States

Opportunity boundaries

  • Recorded funding: See official notice
  • Recorded deadline: May 25, 2029; confirm the closing time.
  • Recorded focus: Research & Science
  • Recorded focus: Health
Fields to verify directly: funding amount. A missing directory value does not remove a restriction.
Connect every eligibility claim, registration, attachment and deadline to the current notice. Open the specific official notice →

Application checklist

How to evaluate and apply for NIH Research Program Projects (Parent P01 Clinical Trial Optional)

Use this record for discovery, then connect every requirement and date to the current official notice and its amendments.

Recorded applicant fit

Government organizations, Universities and higher-education institutions, Nonprofit organizations, Tribal governments, Small businesses, SCHOOLS

Recorded geography

United States

Recorded deadline

May 25, 2029 — confirm the closing time.

Eligibility summary: Special district governments; Public and State controlled institutions of higher education; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Private institutions of higher education; City or township governments; State governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Native American tribal organizations (other than Federally recognized tribal governments); Others (see text field entitled "Additional Information on Eligibility" for clarification); Public housing authorities/Indian housing authorities; County governments; For profit organizations other than small businesses; Small businesses; Native American tribal governments (Federally recognized); Independent school districts

Recorded focus: Research & Science, Health

1Confirm fitMatch entity type, location, project scope, exclusions and cost share.
2Read the noticeCollect amendments, budget rules, attachments and portal instructions.
3Plan timingRecord the funder’s time zone, registrations and internal review dates.
4Submit officiallyUse the funder’s route and save the submission confirmation.

Official sources

Directory link check: October 22, 2026. Always recheck the live notice before relying on it.

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