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Specialized Programs of Research Excellence (SPOREs) in Human Cancers for Years 2027, 2028, and 2029 (P50 Clinical Trial Required)

National Institutes of Health

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications for P50 Research Center Grants for Specialized Programs of Research Excellence (SPOREs). Based on the proposed research, applications may be jointly funded with the National Institute of Dental and Craniofacial R

Funding
See official notice
Deadline
September 25, 2029
Status
OPEN
Category
Research & Science
Opens
October 14, 2026
Directory link check
October 22, 2026

About this opportunity

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications for P50 Research Center Grants for Specialized Programs of Research Excellence (SPOREs). Based on the proposed research, applications may be jointly funded with the National Institute of Dental and Craniofacial Research (NIDCR). This is a re-issuance of PAR-23-284 . The program will fund P50 SPORE grants to support state-of-the-art investigator-initiated translational research that will contribute to improved prevention, early detection, diagnosis, and treatment of an organ-specific cancer or a highly related group of cancers. The research supported through this program must be translational and be based on human biology research using cellular, molecular, structural, biochemical, and/or genetic experimental approaches. SPORE projects must reach a translational human endpoint within the project period of the grant.

Eligibility recorded

State governments; Independent school districts; Special district governments; Public housing authorities/Indian housing authorities; City or township governments; Small businesses; Native American tribal organizations (other than Federally recognized tribal governments); Private institutions of higher education; County governments; Native American tribal governments (Federally recognized); Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Public and State controlled institutions of higher education; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; For profit organizations other than small businesses; Others (see text field entitled "Additional Information on Eligibility" for clarification)

Recorded geography: United States

Applicant types

Focus areas

Research & Science, Health

Directory verification note

Automatically synchronized from Grants.gov Full Taxonomy Expansion. Source identifier: 360541. Confirm details on the official page. This product uses the Grants.gov API but is not endorsed or certified by the U.S. Department of Health and Human Services.

Recorded notice evidence

What to verify for Specialized Programs of Research Excellence (SPOREs) in Human Cancers for Years 2027, 2028, and 2029 (P50 Clinical Trial Required)

Applicant evidence

  • Applicant type: Government organizations
  • Applicant type: SCHOOLS
  • Applicant type: Small businesses
  • Applicant type: Tribal governments
  • Applicant type: Universities and higher-education institutions
  • Applicant type: Nonprofit organizations
  • Geography: United States

Opportunity boundaries

  • Recorded funding: See official notice
  • Recorded deadline: September 25, 2029; confirm the closing time.
  • Recorded focus: Research & Science
  • Recorded focus: Health
Fields to verify directly: funding amount. A missing directory value does not remove a restriction.
Connect every eligibility claim, registration, attachment and deadline to the current notice. Open the specific official notice →

Application checklist

How to evaluate and apply for Specialized Programs of Research Excellence (SPOREs) in Human Cancers for Years 2027, 2028, and 2029 (P50 Clinical Trial Required)

Use this record for discovery, then connect every requirement and date to the current official notice and its amendments.

Recorded applicant fit

Government organizations, SCHOOLS, Small businesses, Tribal governments, Universities and higher-education institutions, Nonprofit organizations

Recorded geography

United States

Recorded deadline

September 25, 2029 — confirm the closing time.

Eligibility summary: State governments; Independent school districts; Special district governments; Public housing authorities/Indian housing authorities; City or township governments; Small businesses; Native American tribal organizations (other than Federally recognized tribal governments); Private institutions of higher education; County governments; Native American tribal governments (Federally recognized); Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Public and State controlled institutions of higher education; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; For profit organizations other than small businesses; Others (see text field entitled "Additional Information on Eligibility" for clarification)

Recorded focus: Research & Science, Health

1Confirm fitMatch entity type, location, project scope, exclusions and cost share.
2Read the noticeCollect amendments, budget rules, attachments and portal instructions.
3Plan timingRecord the funder’s time zone, registrations and internal review dates.
4Submit officiallyUse the funder’s route and save the submission confirmation.

Official sources

Directory link check: October 22, 2026. Always recheck the live notice before relying on it.

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