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Life Sciences Transformational R&D Investment Fund (TRIF) Pilot

UK Government

The Life Sciences Transformational R&D Investment Fund Pilot is a newly established £50 million capital grant opportunity. It aims to boost research and development (R&D) within the UK's Life Sciences sector by supporting large-scale investments focused on innovation and strengthening health resilience. The fund priori

Funding
See official notice
Deadline
April 1, 2028
Status
OPEN
Category
Research & Science
Opens
September 26, 2025
Directory link check
October 24, 2026

About this opportunity

The Life Sciences Transformational R&D Investment Fund Pilot is a newly established £50 million capital grant opportunity. It aims to boost research and development (R&D) within the UK's Life Sciences sector by supporting large-scale investments focused on innovation and strengthening health resilience. The fund prioritises projects with the potential to generate economic benefits. This is a new fund that works alongside the separate Life Sciences Innovative Manufacturing Fund (LSIMF). Projects with a total cost (including capital expenditure) of at least £100 million are eligible to apply. The grant awarded is set at the minimum level necessary to ensure your project proceeds while adhering to UK subsidy regulations, typically ranging from 10-20% of total project costs. For instance, a project with a total cost of £100 million would generally receive a grant of £10-20 million.

Eligibility recorded

Your Company To be considered eligible for the TRIF Pilot, your company must meet the following requirements: Be a UK-registered and wholly private sector business. Operate as a product developer , contract development and manufacturing organisation (CDMO) , or generics manufacturer . Provide two years of audited accounts for the applicant company or parent entity. If unavailable, you must demonstrate that the remaining project funding has been secured. Show a track record of successfully developing or manufacturing medicines or medical devices, either in the UK or internationally. Your Project To be eligible for the fund, your R&D project must: Have a total cost (including eligible capital and non-capital costs) of at least £100m . Be located in the UK . Be primarily a capital investment . Be a single company investment (as opposed to forming a partnership between companies or other types of organisations) Be dependent on the grant to proceed. Projects that would otherwise not occur, be delayed (by three years or more), scaled down, or relocated overseas without the grant may be eligible. R&D Focus Areas Applications are invited to support projects that are engaged in R&D activities within the following key areas: · Human Medicines : This includes projects that focus on the development and innovation of pharmaceuticals, encompassing both active pharmaceutical ingredients (APIs) and finished drug products intended for human use. · Medical Diagnostics : Projects aimed at advancing tools, systems, or methods for the identification and monitoring of diseases. This area covers the R&D of diagnostic technologies that support timely and accurate disease detection. · MedTech Products : This covers the creation and enhancement of medical devices specifically related to human health. Eligible projects may involve the design, testing, or improvement of medical devices. Ineligible Projects: Projects relating to the following are not eligible for funding from the TRIF Pilot: Veterinary medicines Herbal medicines Nutritional supplements or vitamins Raw ingredients (e.g solvents, buffers and cleaning agents) The production of single-use consumables that are not integrated into a larger product (e.g manufacturing syringes independently from diagnostic kits) Secondary packaging for products or materials (e.g package inserts, labelling and boxes)

Recorded geography: United Kingdom

Applicant types

Focus areas

Small Business & Startups

Directory verification note

Automatically synchronized from UK Find a Grant. Source identifier: life-sciences-transformational-rd-investment-fund-trif-pilot-1. Confirm details on the official page.

Recorded notice evidence

What to verify for Life Sciences Transformational R&D Investment Fund (TRIF) Pilot

Applicant evidence

  • Applicant type: Small businesses
  • Geography: United Kingdom

Opportunity boundaries

  • Recorded funding: See official notice
  • Recorded deadline: April 1, 2028; confirm the closing time.
  • Recorded focus: Small Business & Startups
Fields to verify directly: funding amount. A missing directory value does not remove a restriction.
Connect every eligibility claim, registration, attachment and deadline to the current notice. Open the specific official notice →

Application checklist

How to evaluate and apply for Life Sciences Transformational R&D Investment Fund (TRIF) Pilot

Use this record for discovery, then connect every requirement and date to the current official notice and its amendments.

Recorded applicant fit

Small businesses

Recorded geography

United Kingdom

Recorded deadline

April 1, 2028 — confirm the closing time.

Eligibility summary: Your Company To be considered eligible for the TRIF Pilot, your company must meet the following requirements: Be a UK-registered and wholly private sector business. Operate as a product developer , contract development and manufacturing organisation (CDMO) , or generics manufacturer . Provide two years of audited accounts for the applicant company or parent entity. If unavailable, you must demonstrate that the remaining project funding has been secured. Show a track record of successfully developing or manufacturing medicines or medical devices, either in the UK or internationally. Your Project To be eligible for the fund, your R&D project must: Have a total cost (including eligible capital and non-capital costs) of at least £100m . Be located in the UK . Be primarily a capital investment . Be a single company investment (as opposed to forming a partnership between companies or other types of organisations) Be dependent on the grant to proceed. Projects that would otherwise not occur, be delayed (by three years or more), scaled down, or relocated overseas without the grant may be eligible. R&D Focus Areas Applications are invited to support projects that are engaged in R&D activities within the following key areas: · Human Medicines : This includes projects that focus on the development and innovation of pharmaceuticals, encompassing both active pharmaceutical ingredients (APIs) and finished drug products intended for human use. · Medical Diagnostics : Projects aimed at advancing tools, systems, or methods for the identification and monitoring of diseases. This area covers the R&D of diagnostic technologies that support timely and accurate disease detection. · MedTech Products : This covers the creation and enhancement of medical devices specifically related to human health. Eligible projects may involve the design, testing, or improvement of medical devices. Ineligible Projects: Projects relating to the following are not eligible for funding from the TRIF Pilot: Veterinary medicines Herbal medicines Nutritional supplements or vitamins Raw ingredients (e.g solvents, buffers and cleaning agents) The production of single-use consumables that are not integrated into a larger product (e.g manufacturing syringes independently from diagnostic kits) Secondary packaging for products or materials (e.g package inserts, labelling and boxes)

Recorded focus: Small Business & Startups

1Confirm fitMatch entity type, location, project scope, exclusions and cost share.
2Read the noticeCollect amendments, budget rules, attachments and portal instructions.
3Plan timingRecord the funder’s time zone, registrations and internal review dates.
4Submit officiallyUse the funder’s route and save the submission confirmation.

Official sources

Directory link check: October 24, 2026. Always recheck the live notice before relying on it.

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