DoW Amyotrophic Lateral Sclerosis Research Program, Therapeutic Development Award

Defense Health Agency Contracting Activity - DHACA

Funding

Estimated total program funding: $12,000,000

About

Summary: The fiscal year 2026 (FY26) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Therapeutic Development Award (TDA) supports research ranging from preclinical validation of therapeutic leads through U.S. Food and Drug Administration (FDA) Investigational New Drug (IND)-enabling studies. The proposed studies are expected to be empirical in nature and product-driven. Applicants with limited amyotrophic lateral sclerosis (ALS) experience are strongly encouraged to include collaborators with substantial experience in the relevant ALS model systems, endpoints and pathophysiology.Applications supported by this award must begin with lead compounds in hand and must already demonstrate proof-of-concept efficacy data in at least one appropriate preclinical model system of ALS, including whole-animal and cellular model systems.Distinctive Features: Mechanism-specific, predictive/cohort-selective, target engagement and pharmacodynamic biomarker development, in parallel to the main therapeutic effort, is a critical component of the FY26 ALSRP Therapeutic Development Award. If appropriate mechanism-specific biomarkers are already available or currently in development, how the existing biomarkers will improve trial design, patient selection, and efficiency or interpretation of the proposed ALS therapeutic approach must be apparent in the application. Development of biomarkers for the purposes of diagnosis, prognosis, or measurement of general disease progression without consideration of the therapeutic development process will not be supported.Therapeutic candidates which have already been granted an IND are not appropriate for this mechanism.

Applicant types

Grants.gov eligibility code 99

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Notice-specific evidence check

What an applicant must verify for DoW Amyotrophic Lateral Sclerosis Research Program, Therapeutic Development Award

Applicant evidence

Applicant type: Unrestricted applicants

Opportunity boundaries

Recorded funding: Estimated total program funding: $12,000,000
Recorded deadline: October 1, 2026; confirm time zone and submission system.
Recorded focus: Science, technology and research

Do not infer missing fields: geographic eligibility. Absence from this directory record is not evidence that a restriction does not exist.

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Application checklist

How to apply for DoW Amyotrophic Lateral Sclerosis Research Program, Therapeutic Development Award

The steps below turn the recorded grant fields into a pre-submission check. They do not replace the current Notice of Funding Opportunity or its amendments.

Recorded eligibility

• Applicant types: Grants.gov eligibility code 99.
• Geographic scope is not structured in this record.
• No sufficiently specific eligibility summary is stored.

Focus areas: ST

Recorded deadline

September 30, 2026 — confirm the time zone and submission system

A missing or rolling date is not permission to assume an open application window.

1. Confirm fitMatch your applicant type, location, project scope and any cost-share or registration rule to the official notice.
2. Read the noticeCollect the current guidelines, amendments, budget rules, required attachments and submission instructions.
3. Check timingRecord the deadline time zone, internal review date and any earlier registration or portal cut-off.
4. Submit thereUse the official application route and save the confirmation or submission reference.

Official sources

Recorded source: https://www.grants.gov/xml-extract

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Last directory verification: Sep 14, 2026.