DoW Amyotrophic Lateral Sclerosis Research Program, Pilot Clinical Trial Award

Defense Health Agency Contracting Activity - DHACA

Funding

Estimated total program funding: $5,600,000

About

Summary: The fiscal year 2026 (FY26) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Pilot Clinical Trial Award (PCTA) supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of amyotrophic lateral sclerosis (ALS). Projects may range from phase 1 to small-scale phase 2 trials.Applications must address one of the following focus areas:· Biomarker-Driven Interventions: Disease-modifying interventions, with mechanism-specific biomarkers to predict which clinical trial participants are likely to respond, demonstrate target engagement, and effects on the intended biological pathway.· Clinical Care: Improving aspects of clinical care and symptom management for ALS.Distinctive Features: Funding from this award mechanism must support a clinical trial. The clinical trial should begin no later than 12 months after the award date or 18 months for U.S. Food and Drug Administration (FDA)-regulated studies.Projects proposing a therapeutic intervention (drug, biologic, and/or device) must incorporate biomarkers specific to the intervention into the trial design.All pre-applications and applications are required to incorporate community collaboration, as described in Section 3.2.2, to optimize research impact.Applications must include a detailed Regulatory Strategy plan that outlines the approach for obtaining regulatory approvals, if required, specifically for the funded portion of the study. In addition, applications must provide a separate Transition Plan that describes how the outcomes of the study will be advanced to the next phase of development, beyond the scope of the funded work.

Applicant types

Grants.gov eligibility code 99

Visit Official Funding Page →

Continue researching

Related current grants

All Research & Science grants →

CHIPS Research and Development Office (CRDO) Broad Agency Announcement (BAA)

National Institute of Standards and Technology

NIST is soliciting proposals from eligible applicants for research, prototyping, and commercial solutions that advance microelectronics technology in the U.S., to be considered for funding by the CHIPS Research and Development Office (CRDO).

Measurement Science and Engineering (MSE) Research Grant Programs

National Institute of Standards and Technology

To support activities that develop, expand, strengthen, or sustain NIST partnership programs and/or support the conduct of research or a recipient's portion of collaborative research in a variety of areas including, but not limited to: Metrology; Standards; Nanotechnology; Artificial Intelligen

Probability

U.S. National Science Foundation

The Probability Program supports research on the theory and applications of probability. Subfields include discrete probability, stochastic processes, limit theory, interacting particle systems, stochastic differential and partial differential equations, and Markov processes. Research in probability

NSF Dynamic Language Infrastructure - NEH Documenting Endangered Languages

U.S. National Science Foundation

This funding partnership between the National Science Foundation (NSF) and the National Endowment for the Humanities (NEH) supports projects to develop and advance knowledge concerning dynamic language infrastructure in the context of endangered human languages — languages that are both unders

Notice-specific evidence check

What an applicant must verify for DoW Amyotrophic Lateral Sclerosis Research Program, Pilot Clinical Trial Award

Applicant evidence

Applicant type: Unrestricted applicants

Opportunity boundaries

Recorded funding: Estimated total program funding: $5,600,000
Recorded deadline: October 1, 2026; confirm time zone and submission system.
Recorded focus: Science, technology and research

Do not infer missing fields: geographic eligibility. Absence from this directory record is not evidence that a restriction does not exist.

Before investing in an application, connect every eligibility claim, required registration, submission component and deadline to the current official notice. Open the recorded official source →

Application checklist

How to apply for DoW Amyotrophic Lateral Sclerosis Research Program, Pilot Clinical Trial Award

The steps below turn the recorded grant fields into a pre-submission check. They do not replace the current Notice of Funding Opportunity or its amendments.

Recorded eligibility

• Applicant types: Grants.gov eligibility code 99.
• Geographic scope is not structured in this record.
• No sufficiently specific eligibility summary is stored.

Focus areas: ST

Recorded deadline

September 30, 2026 — confirm the time zone and submission system

A missing or rolling date is not permission to assume an open application window.

1. Confirm fitMatch your applicant type, location, project scope and any cost-share or registration rule to the official notice.
2. Read the noticeCollect the current guidelines, amendments, budget rules, required attachments and submission instructions.
3. Check timingRecord the deadline time zone, internal review date and any earlier registration or portal cut-off.
4. Submit thereUse the official application route and save the confirmation or submission reference.

Official sources

Recorded source: https://www.grants.gov/xml-extract

Open official notice →

Last directory verification: Sep 14, 2026.