HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)

National Institutes of Health

Funding

Varies

About

The purpose of this initiative is to: (1) support the efforts by R15-eligible Principal Investigators (PIs) to conduct rigorous basic and/or mechanistic pain research projects; (2) promote integrated, interdisciplinary research partnerships between R15-eligible PIs and additional investigators from U.S. domestic institutions, and (3) enhance the pain research environment at the R15-eligible institution for health professional trainees or undergraduate and/or graduate students by actively engaging them in the proposed pain research projects.

Eligibility

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Applicant types

Grants.gov eligibility code 06 Grants.gov eligibility code 20 Grants.gov eligibility code 25

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Notice-specific evidence check

What an applicant must verify for HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)

Applicant evidence

Applicant type: Public and state-controlled institutions of higher education
Applicant type: Private institutions of higher education
Applicant type: Other eligible applicants

Opportunity boundaries

Recorded funding: Up to USD 375,000
Recorded deadline: November 24, 2026; confirm time zone and submission system.
Recorded focus: Health
Recorded focus: Information and statistics

Do not infer missing fields: geographic eligibility. Absence from this directory record is not evidence that a restriction does not exist.

Before investing in an application, connect every eligibility claim, required registration, submission component and deadline to the current official notice. Open the recorded official source →

Application checklist

How to apply for HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)

The steps below turn the recorded grant fields into a pre-submission check. They do not replace the current Notice of Funding Opportunity or its amendments.

Recorded eligibility

• Applicant types: Grants.gov eligibility code 06, Grants.gov eligibility code 20, Grants.gov eligibility code 25.
• Geographic scope is not structured in this record.
• Notice summary: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Focus areas: HL, ISS

Recorded deadline

November 23, 2026 — confirm the time zone and submission system

A missing or rolling date is not permission to assume an open application window.

1. Confirm fitMatch your applicant type, location, project scope and any cost-share or registration rule to the official notice.
2. Read the noticeCollect the current guidelines, amendments, budget rules, required attachments and submission instructions.
3. Check timingRecord the deadline time zone, internal review date and any earlier registration or portal cut-off.
4. Submit thereUse the official application route and save the confirmation or submission reference.

Official sources

Recorded source: https://www.grants.gov/xml-extract

Open official notice →

Last directory verification: Sep 13, 2026.