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Cutting-Edge Basic Research Awards (CEBRA) (R21 Clinical Trial Optional)

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Funding: Estimated total program funding: $150,000
Deadline: August 12, 2027
Status: OPEN
Category: Research & Science
Opens: December 30, 2024
Directory link check: October 27, 2026

About this opportunity

The National Institute on Drug Abuse (NIDA) Cutting-Edge Basic Research Award (CEBRA) is designed to foster highly innovative or conceptually creative research related to the etiology, pathophysiology, prevention, or treatment of substance use disorders (SUDs). It supports high-risk and potentially high-impact research that is sparse or not included in NIDA's current portfolio that has the potential to transform SUD research. The proposed research should: 1. develop, and/or adapt, revolutionary techniques or methods for addiction research or that show promising future applicability to SUD research; and /or 2. test an innovative and significant hypothesis for which there are scant precedent or preliminary data and which, if confirmed, would transform current thinking.

Eligibility recorded

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Applicant types

State governments County governments City or township governments Special district governments Independent school districts Public and state-controlled institutions of higher education Federally recognized tribal governments Public housing authorities and Indian housing authorities Native American tribal organizations 501(c)(3) nonprofits other than higher-education institutions Nonprofits without 501(c)(3) status other than higher-education institutions Private institutions of higher education For-profit organizations other than small businesses Small businesses Other eligible applicants

Focus areas

Education, Health

Recorded notice evidence

What to verify for Cutting-Edge Basic Research Awards (CEBRA) (R21 Clinical Trial Optional)

Applicant evidence

Applicant type: State governments
Applicant type: County governments
Applicant type: City or township governments
Applicant type: Special district governments
Applicant type: Independent school districts
Applicant type: Public and state-controlled institutions of higher education
Applicant type: Federally recognized tribal governments
Applicant type: Public housing authorities and Indian housing authorities

Opportunity boundaries

Recorded funding: Estimated total program funding: $150,000
Recorded deadline: August 12, 2027; confirm the closing time.
Recorded focus: Education
Recorded focus: Health

Connect every eligibility claim, registration, attachment and deadline to the current notice. Open the specific official notice →

Application checklist

How to evaluate and apply for Cutting-Edge Basic Research Awards (CEBRA) (R21 Clinical Trial Optional)

Use this record for discovery, then connect every requirement and date to the current official notice and its amendments.

Recorded applicant fit

State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and state-controlled institutions of higher education

Recorded geography

No structured geographic scope is recorded.

Recorded deadline

August 12, 2027 — confirm the closing time.

Eligibility summary: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Recorded focus: Education, Health

1Confirm fitMatch entity type, location, project scope, exclusions and cost share.

2Read the noticeCollect amendments, budget rules, attachments and portal instructions.

3Plan timingRecord the funder’s time zone, registrations and internal review dates.

4Submit officiallyUse the funder’s route and save the submission confirmation.

Official sources

Directory link check: October 27, 2026. Always recheck the live notice before relying on it.

Open specific official notice →

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