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NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)

National Institutes of Health

The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel

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Funding
See official notice
Deadline
January 8, 2028
Status
OPEN
Category
Research & Science
Opens
December 18, 2024
Directory link check
October 27, 2026

About this opportunity

The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research.

Eligibility recorded

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Applicant types

State governmentsCounty governmentsCity or township governmentsSpecial district governmentsIndependent school districtsPublic and state-controlled institutions of higher educationFederally recognized tribal governmentsPublic housing authorities and Indian housing authoritiesNative American tribal organizations501(c)(3) nonprofits other than higher-education institutionsNonprofits without 501(c)(3) status other than higher-education institutionsPrivate institutions of higher educationFor-profit organizations other than small businessesSmall businessesOther eligible applicants

Focus areas

Education, Environment, Health, Information and statistics

Recorded notice evidence

What to verify for NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)

Applicant evidence

  • Applicant type: State governments
  • Applicant type: County governments
  • Applicant type: City or township governments
  • Applicant type: Special district governments
  • Applicant type: Independent school districts
  • Applicant type: Public and state-controlled institutions of higher education
  • Applicant type: Federally recognized tribal governments
  • Applicant type: Public housing authorities and Indian housing authorities

Opportunity boundaries

  • Recorded funding: See official notice
  • Recorded deadline: January 8, 2028; confirm the closing time.
  • Recorded focus: Education
  • Recorded focus: Environment
  • Recorded focus: Health
  • Recorded focus: Information and statistics
Fields to verify directly: funding amount. A missing directory value does not remove a restriction.
Connect every eligibility claim, registration, attachment and deadline to the current notice. Open the specific official notice →

Application checklist

How to evaluate and apply for NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)

Use this record for discovery, then connect every requirement and date to the current official notice and its amendments.

Recorded applicant fit

State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and state-controlled institutions of higher education

Recorded geography

No structured geographic scope is recorded.

Recorded deadline

January 8, 2028 — confirm the closing time.

Eligibility summary: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Recorded focus: Education, Environment, Health, Information and statistics

1Confirm fitMatch entity type, location, project scope, exclusions and cost share.
2Read the noticeCollect amendments, budget rules, attachments and portal instructions.
3Plan timingRecord the funder’s time zone, registrations and internal review dates.
4Submit officiallyUse the funder’s route and save the submission confirmation.

Official sources

Directory link check: October 27, 2026. Always recheck the live notice before relying on it.

Open specific official notice →

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