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Public Health Crisis Response Cooperative Agreement

Centers for Disease Control - OPHPR

CDC seeks to enhance the nation’s ability to rapidly mobilize, surge, and respond to public health emergencies (PHEs) as identified by CDC by establishing a roster of approved but unfunded (ABU) applicants that may receive rapid funding to respond to PHEs of such magnitude, complexity, or sign

Funding
Estimated total program funding: $500,000,000
Category
Health & Medical
Status
OPEN
Deadline
2/12/2027

About

CDC seeks to enhance the nation’s ability to rapidly mobilize, surge, and respond to public health emergencies (PHEs) as identified by CDC by establishing a roster of approved but unfunded (ABU) applicants that may receive rapid funding to respond to PHEs of such magnitude, complexity, or significance that they would have an overwhelming impact upon, and exceed resources available to, the jurisdictions. Applicants will undergo an objective merit review process, and entities that successfully meet the requirements for approval will be placed on the ABU list. CDC will use this ABU list for emergencies that require federal support to effectively respond to, manage, and address identified public health threats. CDC will make funding related to this NOFO available once it has determined a public health emergency exists or is considered imminent and will be contingent upon the availability and stipulations of appropriations. CDC will provide additional guidance and information to those on the ABU list when this NOFO is funded. Since this NOFO is designed to collect applications prior to a PHE, applicants are encouraged to submit work plans and budgets that demonstrate their ability to respond to a PHE. COVID-19 public health response plans, such as plans funded under CDC-RFA-TP18-1802 in 2020 are acceptable for this purpose. If this NOFO is funded for a specific PHE, CDC will develop supplemental guidance that outlines additional work plan and budget requirements tailored to the emergency. This NOFO is not a capacity-building funding mechanism, and it is not intended to create or establish new public health (PH) emergency management programs. It may be used to re- establish capacity lost or diminished because of the public health crisis. It is designed to support the surge needs of existing programs responding to a significant PHE. CDC will provide supplemental guidance to entities on the ABU list when this NOFO is activated regarding specific activities intended to address the emergency. CDC has strong relationships with governmental PH departments, community-based organizations, and other domestic partners and supports them for planning, capacity-building, preparedness, and response to PHEs. This NOFO complements these ongoing capacity-building preparedness and response programs by providing a mechanism for CDC to rapidly mobilize and fund PH organizations for specific response needs. Applicants must describe how this funding will not duplicate or supplant other federal funding. Upon occurrence of a PHE, CDC can rapidly fund specific applicants to accelerate public health crisis response activities such as coordinating emergency operations, hiring surge staff, and conducting needs assessments to determine the resources necessary to address the public health crisis. The NOFO also provides funding for specialized public health emergency response activities tailored to the specific public health crisis.

Eligibility

This NOFO is intended for states, political subdivisions of states, and other public entities as specified in section 317(a) of the Public Health Service Act (42 USC § 247(b)). It targets public health organizations that serve state, tribal, local, and territorial populations and are constitutionally empowered to protect the health and welfare of their respective communities, focused on executing emergency preparedness and response services. To demonstrate existing capacity for public health emergency management, applicants must submit their response organizational charts and work plans. If these documents are not submitted, the application will be considered non-responsive and will receive no further review. Local government organizations or their bona fide agents must:Serve a county population of 2 million or more or serve a city population of 400,000 or more. Populations for county and city jurisdictions are based on the following 2021 U.S. Census resources:City and Town Population Totals: 2020-2021 (census.gov) U.S. Census – Annual Estimates of the Resident Population for Incorporated Places, Ranked by July 1, 2021, Population: April 1, 2020, to July 1, 2021County Population Totals: 2020-2021 (census.gov) U.S. Census – Annual Estimates for 2021Sources may be updated as census data change over timeLocal jurisdictions that meet population requirements are listed in Attachment A.Tribal governments or their bona fide agents must be federally recognized and:Serve a population of 50,000 or more.CDC will reopen this announcement periodically over the five-year NOFO period to accommodate population changes and ensure we maintain a current roster of eligible jurisdictions for emergency response. Sources for future postings of this NOFO will be based on the latest census data and may change over time.The anticipated dates for reposting are noted below. Applicants will have 60 days to submit an application.July 2024July 2025July 2026

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Notice-specific evidence check

What an applicant must verify for Public Health Crisis Response Cooperative Agreement

Applicant evidence

  • Applicant type: State governments
  • Applicant type: County governments
  • Applicant type: City or township governments
  • Applicant type: Special district governments
  • Applicant type: Federally recognized tribal governments
  • Applicant type: Other eligible applicants

Opportunity boundaries

  • Recorded funding: Estimated total program funding: $500,000,000
  • Recorded deadline: February 12, 2027; confirm time zone and submission system.
  • Recorded focus: Health
Before investing in an application, connect every eligibility claim, required registration, submission component and deadline to the current official notice. Open the recorded official source →

Application checklist

How to apply for Public Health Crisis Response Cooperative Agreement

The steps below turn the recorded grant fields into a pre-submission check. They do not replace the current Notice of Funding Opportunity or its amendments.

Recorded eligibility

  • Applicant types: Grants.gov eligibility code 00, Grants.gov eligibility code 01, Grants.gov eligibility code 02, Grants.gov eligibility code 04, Grants.gov eligibility code 07, Grants.gov eligibility code 25.
  • Geographic scope is not structured in this record.
  • Notice summary: This NOFO is intended for states, political subdivisions of states, and other public entities as specified in section 317(a) of the Public Health Service Act (42 USC § 247(b)). It targets public health organizations that serve state, tribal, local, and territorial populations and are constitutionally empowered to protect the health and welfare of their respective communities, focused on executing emergency preparedness and response services. To demonstrate existing capacity for public health emergency management, applicants must submit their response organizational charts and work plans. If these documents are not submitted, the application will be considered non-responsive and will receive no further review. Local government organizations or their bona fide agents must:Serve a county population of 2 million or more or serve a city population of 400,000 or more. Populations for county and city jurisdictions are based on the following 2021 U.S. Census resources:City and Town Population Totals: 2020-2021 (census.gov) U.S. Census – Annual Estimates of the Resident Population for Incorporated Places, Ranked by July 1, 2021, Population: April 1, 2020, to July 1, 2021County Population Totals: 2020-2021 (census.gov) U.S. Census – Annual Estimates for 2021Sources may be updated as census data change over timeLocal jurisdictions that meet population requirements are listed in Attachment A.Tribal governments or their bona fide agents must be federally recognized and:Serve a population of 50,000 or more.CDC will reopen this announcement periodically over the five-year NOFO period to accommodate population changes and ensure we maintain a current roster of eligible jurisdictions for emergency response. Sources for future postings of this NOFO will be based on the latest census data and may change over time.The anticipated dates for reposting are noted below. Applicants will have 60 days to submit an application.July 2024July 2025July 2026

Focus areas: HL

Recorded deadline

February 11, 2027 — confirm the time zone and submission system

A missing or rolling date is not permission to assume an open application window.

  1. 1. Confirm fitMatch your applicant type, location, project scope and any cost-share or registration rule to the official notice.
  2. 2. Read the noticeCollect the current guidelines, amendments, budget rules, required attachments and submission instructions.
  3. 3. Check timingRecord the deadline time zone, internal review date and any earlier registration or portal cut-off.
  4. 4. Submit thereUse the official application route and save the confirmation or submission reference.

Official sources

Recorded source: https://www.grants.gov/xml-extract

Last directory verification: Sep 13, 2026.